• 文部科学省
  • JSPS
  • 科研費
  • ユビキチンネオバイオロジー
  • ユビキチンネオバイオロジー
研究成果

研究成果

Publications

研究成果

論文等研究成果の謝辞に関するお願い

本新学術領域研究により得た研究成果を発表する場合は、Acknowledgment(謝辞)に、科研費による助成を受けた旨を記載してください。

  • 論文に関する科研費が本新学術領域研究一つの場合:This work was supported by MEXT KAKENHI Grant Number JP(8桁の課題番号).
  • 論文に関する科研費が複数(日本学術振興会科研費を含む)の場合:This work was supported by MEXT/JSPS KAKENHI Grant Numbers JP(8桁の課題番号), JP(8桁の課題番号), and JP(8桁の課題番号).

(記入例1)
Acknowledgements
We thank the beamline staff of the biological crystallography beamlines of BL41XU of SPring-8 (Hyogo, Japan) for technical help during data collection. This work was supported by JSPS/MEXT KAKENHI (JP16H0XXXX to Y.S., JP18K14YYY to H.T., and JP18H05ZZZ to S.F.), and TTTTT Science Foundation (to Y.S. and K.T.).

(記入例2)
Acknowledgements
We thank S. Sato, K. Ito, and T. Saito for reagents. This research was supported by MEXT/JSPS KAKENHI Grant Numbers JP18K14XXX (H.T.), JP18H05XXX (F.O. and Y.S.), JP19H0XXX (T.I.) and JP21000XXX (K.T.); the TTTTT Science Foundation (Y.S., K.T., and T.I.); and the UUUU Memorial Foundation (Y.S.).

詳しくはこちら

 

原著論文 / Publication

  1. Okatsu K, Sato Y, Yamano K, Matsuda N, Negishi L, Takahashi A, Yamagata A, Goto-Ito S, Mishima M, Ito Y, Oka T, Tanaka K, Fukai S.
    Structural insights into ubiquitin phosphorylation by PINK1.
    Sci. Rep. 8, 10382 (2018)
    PMID: 29991771
  2. Nishiyama Y, Fujii S, Makishima M, Hashimoto Y, Ishikawa M.
    Efficient lead finding, activity enhancement and preliminary selectivity control of nuclear receptor ligands bearing a phenanthridinone skeleton.
    Int. J. Mol. Sci. 19, 2090 (2018)
    PMID: 30021999
  3. Sohtome Y, Shimazu T, Barjau J, Fujishiro S, Akakabe M, Terayama N, Dodo K, Ito A, Yoshida M, Shinkai Y, Sodeoka M.
    Unveiling epidithiodiketopiperazine as a non-histone arginine methyltransferase inhibitor by chemical protein methylome analyses.
    Chem. Commun. 54, 9202-9205 (2018)
    PMID: 30063235
  4. Hiranaka S, Tega Y, Higuchi K, Kurosawa T, Deguchi Y, Arata M, Ito A, Yoshida M, Nagaoka Y, Sumiyoshi T.
    Design, Synthesis, and Blood-Brain Barrier Transport Study of Pyrilamine Derivatives as Histone Deacetylase Inhibitors.
    ACS Med. Chem. Lett. 9, 884-888 (2018)
    PMID: 30258535
  5. Shibata N, Shimokawa K, Nagai K, Ohoka N, Hattori T, Miyamoto N, Ujikawa O, Sameshima T, Nara H, Cho N, Naito M.
    Pharmacological difference between degrader and inhibitor against oncogenic BCR-ABL kinase.
    Sci. Rep. 8, 13549 (2018)
    PMID: 30202081
  6. Furuta H, Yoshihara H, Fukushima T, Yoneyama Y, Ito A, Worrall C, Girnita A, Girnita L, Yoshida M, Asano T, Komada M, Kataoka N, Chida K, Hakuno F, Takahashi SI.
    IRS-2 deubiquitination by USP9X maintains anchorage-independent cell growth via Erk1/2 activation in prostate carcinoma cell line.
    Oncotarget 9, 33871-33883 (2018)
    PMID: 30338032
  7. Azuma Y, Imai H, Kawaguchi Y, Nakase I, Kimura H, Futaki S.
    Modular redesign of a cationic lytic peptide to promote the endosomal escape of biomacromolecules.
    Angew. Chem. Int. Ed. Engl. 57, 12771 (2018)
    PMID: 30101453
  8. Nakamoto Y, Pradipta AR, Mukai H, Zouda M, Watanabe Y, Kurbangalieva A, Ahmadi P, Manabe Y, Fukase K, Tanaka K.
    Expanding the applicability of the metal labeling of biomolecules by the RIKEN click reaction: A case study with Gallium-68 positron emission tomography.
    ChemBioChem. 19, 2055-2060 (2018)
    PMID: 30066425
  9. Wu W, Sahara K, Hirayama S, Zhao X, Watanabe A, Hamazaki J, Yashiroda H, Murata S.
    PAC1‐PAC2 proteasome assembly chaperone retains the core α4–α7 assembly intermediates in the cytoplasm.
    Genes to Cells 23, 839–848 (2018)
    PMID: 30133132
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    Predicting bioprocess targets of chemical compounds through integration of chemical-genetic and genetic interactions.
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    HOIL1 is essential for the induction of type I and III interferons by MDA5 and regulates persistent murine norovirus infection.
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    Cascade reaction in human live tissue allows clinically applicable diagnosis of breast cancer morphology.
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    RK-287107, a potent and specific tankyrase inhibitor, blocks colorectal cancer cell growth in a preclinical model.
    Cancer Sci. 109, 4003-4014 (2018)
    PMID: 30238564
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    Chemistry-driven Epigenetic Investigation of Histone and DNA Modifications.
    Chem. Rec. 18, 1727-1744 (2018)
    PMID: 30070422
  15. Kamo N, Hayashi G, Okamoto A.
    Triple Function of 4-Mercaptophenylacetic Acid Promotes One-Pot Multiple Peptide Ligation.
    Angew. Chem. Int. Ed. 57, 16533-16537 (2018)
    PMID: 30346110
    Highlighted in SYNFACTS 15, 0204 (2018)
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    Specific modification of aged proteasomes revealed by tag-exchangeable knock-in mice.
    Mol. Cell Biol. 39, e00426-18 (2018)
    PMID: 30348842
  17. Shioi R, Toyota Y, Noguchi-Yachide T, Ishikawa M. Yamaguchi T, Makishima M, Hashimoto Y, Ohgane K.
    Unexpected emergence of luciferase-inhibitory activity during structural development study of phenyloxadiazole-based PPAR ligands.
    Heterocycles 97, 854-864 (2018)

 

総説論文・書籍 / Review・Book

  1. *Murata S, *Takahama Y, *Kasahara M, *Tanaka K.
    The immunoproteasome and thymoproteasome: functions, evolution and human disease.
    Nat. Immunol. 19, 923–931(2018)
    PMID: 30104634
  2. Koizumi S, Hamazaki J, *Murata S.
    Transcriptional regulation of the 26S proteasome by Nrf1.
    Proc. Jpn. Acad. Ser. B 94, 325–336 (2018)
    PMID: 30305478
  3. Robaa D, Monaldi D, Wössner N, Kudo N, Rumpf T, Schiedel M, Yoshida M, *Jung M.
    Opening the selectivity pocket in the human lysine deacetylase sirtuin2 - new opportunities, new questions.
    Chem. Rec. 18, 1701-1707 (2018)
    PMID: 29931800
  4. Sueoka T, Koyama K, Hayashi G, *Okamoto A.
    Chemistry-driven Epigenetic Investigation of Histone and DNA Modifications.
    Chem. Rec. 18, 1727-1744 (2018)
    PMID: 30070422

 

日本語総説/ Review in Japanese

  1. 大岡伸通、*内藤幹彦:「蛋白質分解医薬品の開発動向」医薬品医療機器レギュラトリーサイエンス 第49巻第8号513-524 (2018)
  2. 大岡伸通、*内藤幹彦:「標的タンパク質を分解する新たな低分子薬の開発技術」実験医学 第36巻第18号3125-3132 (2018)
  3. 佐々木克博、*岩井 一宏:「多様化するユビキチンコード」医学のあゆみ『蛋白質代謝医学-構造・機能の研究から臨床応用まで』第267巻13号989-995 (2018)
  4. 柴田識人、*内藤幹彦:「標的蛋白質の分解を誘導するハイブリッド化合物SNIPERsとPROTACs」医学のあゆみ『蛋白質代謝医学-構造・機能の研究から臨床応用まで』第267巻13号1069-1075 (2018)
  5. *伊藤拓水、半田 宏:「セレブロンモジュレーター」医学のあゆみ『蛋白質代謝医学-構造・機能の研究から臨床応用まで』第267巻13号1076-1081 (2018)
  6. *佐伯 泰:「生体分子の液-液相分離」医学のあゆみ『蛋白質代謝医学-構造・機能の研究から臨床応用まで』第267巻13号1082-1088 (2018)

 

原著論文 / Publication

  1. Tomaru U, Konno S, Miyajima S, Kimoto R, Onodera M, Kiuchi S, Murata S, Ishizu A, Kasahara M.
    Restricted Expression of the Thymoproteasome Is Required for Thymic Selection and Peripheral Homeostasis of CD8+ T Cells.
    Cell Rep. 26, 639-651. e2 (2019)
    PMID: 3065037
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    PMID: 30635653
  4. Izuta S, Yamaguchi S, Kosaka T, Okamoto A.
    Reversible and Photoresponsive Immobilization of Nonadherent Cells by Spiropyran-Conjugated PEG-Lipids.
    ACS Appl. Bio Mater. 2, 33-38 (2019)
  5. Kawaguchi Y, Ise S, Azuma Y, Takeuchi T, Kawano K, Le TK, Ohkanda J, Futaki S.
    Dipicolylamine/metal complexes that promote direct cell-membrane penetration of octaarginine.
    Bioconjug. Chem. 30, 454-460 (2019)
    PMID: 30428256
  6. Ikeuchi K, Tesina P, Matsuo Y, Sugiyama T, Cheng J, Saeki Y, Tanaka K, Becker T, Beckmann R, Inada T.
    Collided ribosomes form a unique structural interface to induce Hel2-driven quality control pathways.
    EMBO J. 38, e100276 (2019)
    PMID: 30609991
  7. Hitachi K, Nakatani M, Takasaki A, Ouchi Y, Uezumi A, Ageta H, Inagaki H, Kurahashi H, Tsuchida K.
    Myogenin promoter-associated lncRNA Myoparr is essential for myogenic differentiation.
    EMBO Rep. 20, e47468 (2019)
    PMID: 30622218
  8. Ohoka N, Ujikawa O, Shimokawa K, Sameshima T, Shibata N, Hattori T, Nara H, Cho N, Naito M.
    Different Degradation Mechanisms of Inhibitor of Apoptosis Proteins (IAPs) by the Specific and Nongenetic IAP-Dependent Protein Eraser (SNIPER).
    Chem. Pharm. Bull. 67, 203-209 (2019)
    PMID: 30369550
  9. Suvarna K, Honda K, Muroi M, Kondoh Y, Osada H, Watanabe N.
    A small-molecule ligand of valosin-containing protein/p97 inhibits cancer cell-accelerated fibroblast migration.
    J. Biol. Chem. 294, 2988-2996 (2019)
    PMID: 30610116
  10. Otsubo R, Mimuro H, Ashida H, Hamazaki J, Murata S, Sasakawa C.
    Shigella effector IpaH4.5 targets 19S regulatory particle subunit RPN13 in the 26S proteasome to dampen cytotoxic T lymphocyte activation.
    Cell. Microbiol. 21, e12974 (2019)
    PMID: 30414351
  11. Hayashi G, Yanase M, Nakatsuka Y, Okamoto A.
    Simultaneous and Traceless Ligation of Peptide Fragments on DNA Scaffold.
    Biomacromolecules 20, 1246-1253 (2019)
    PMID: 30677290
  12. Ling F, Bradshaw E, Yoshida M.
    Prevention of mitochondrial genomic instability in yeast by the mitochondrial recombinase Mhr1.
    Sci. Rep. 9, 5433 (2019)
    PMID: 30931958
  13. Takahashi T, Minami S, Tajima K, Tsuchiya Y, Sakai N, Suga K, Hisanaga S, Obayashi N, Fukuda M, Kawahara H.
    Cytoplasmic control of Rab-family small GTPases through BAG6.
    EMBO Rep. 20, e46794 (2019)
    PMID: 30804014
  14. Ishii N, Walinda E, Iwakawa N, Morimoto D, Iwai K, Sugase K, Shirakawa M.
    NMR resonance assignments of the NZF domain of mouse HOIL-1L free and bound to linear di-ubiquitin.
    Biomol. NMR Assign. 13, 149-153 (2019)
    PMID: 30569274
  15. Misawa T, Goto C, Shibata N, Hirano M, Kikuchi Y, Naito M, Demizu Y.
    Rational design of novel amphipathic antimicrobial peptides focused on distribution of cationic amino acid residues.
    MedChemComm 10,896-900 (2019)
    PMID: 31303986
  16. Shirai F, Tsumura T, Yashiroda Y, Yuki H, Niwa H, Sato S, Chikada T, Koda Y, Washizuka K, Yoshimoto N, Abe M, Onuki T, Mazaki Y, Hirama C, Fukami T, Watanabe H, Honma T, Umehara T, Shirouzu M, Okue M, Kano Y, Watanabe T, Kitamura K, Shitara E, Muramatsu Y, Yoshida H, Mizutani A, Seimiya H, Yoshida M, Koyama H.
    Discovery of Novel Spiroindoline Derivatives as Selective Tankyrase Inhibitors.
    J. Med. Chem. 62, 3407-3427 (2019)
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  17. Demizu S, Asaka N, Kawahara H, Sasaki E.
    TAS-203, an oral phosphodiesterase 4 inhibitor, exerts anti-inflammatory activities in a rat airway inflammation model.
    Eur. J. Pharmacol. 849, 22-29 (2019)
    PMID: 30716315
  18. Takahashi TS, Sato Y, Yamagata A, Goto-Ito S, Saijo M, Fukai S.
    Structural basis of ubiquitin recognition by the winged-helix domain of Cockayne syndrome group B protein.
    Nucleic Acids Res. 47, 3784-3794 (2019)
    PMID: 30753618
  19. Yanase M, Nakatsu K, Cardos C J, Konda Y, Hayashi G, Okamoto A.
    Cysteinylprolyl Imide (CPI) Peptide: A Highly Reactive and Easily Accessible Crypto-thioester for Chemical Protein Synthesis.
    Chem. Sci. 10, 5967-5975 (2019)
    PMID: 31360403
  20. Yamaguchi S, Higashi K, Azuma T, Okamoto A.
    Supramolecular Polymeric Hydrogels for Ultrasound-guided Protein Release.
    Biotechnol. J. 14, 1800530 (2019)
    PMID: 30810275
  21. Shu K, Iwamoto N, Honda K, Kondoh Y, Hirano H, Osada H, Ohno H, Fujii N, Oishi S.
    Development of mirror-image screening systems for XIAP BIR3 domain inhibitors.
    Bioconjug. Chem. 30, 1395-1404 (2019)
    PMID: 30888797
  22. Ando H, Sato T, Ito T, Yamamoto J, Sakamoto S, Nitta N, Asatsuma-Okumura T, Shimizu N, Mizushima R, Aoki I, Imai T, Yamaguchi Y, Berk AJ, Handa H.
    Cereblon Control of Zebrafish Brain Size by Regulation of Neural Stem Cell Proliferation.
    iScience 15, 95-108 (2019)
    PMID: 31055217
    プレスリリース
  23. Bai M, Zhao X, Sahara K, Ohte Y, Hirano Y, Kaneko T, Yashiroda H, Murata S.
    In-depth Analysis of the Lid Subunits Assembly Mechanism in Mammals.
    Biomolecules 9, E213 (2019)
    PMID: 31159305
  24. Qi Y, Zhao X, Chen J, Pradipta AR, Wei J, Ruan H, Zhou L, Hsung R P, Tanaka K.
    In vitro and in vivo cancer cell apoptosis triggered by competitive binding of Cinchona alkaloids to the RING domain of TRAF6.
    Biosci. Biotechnol. Biochem. 83, 1011-1026 (2019)
    PMID: 31074699
  25. Mashita T, Kowada T, Takahashi H, Matsui T, Mizukami S.
    Light-wavelength-based Quantitative Control of Dihydrofolate Reductase Activity Using Photochromic Isostere of Inhibitor.
    ChemBioChem 20, 1382–1386 (2019)
    PMID: 30656808
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    The anti-cancer drug gefitinib accelerates Fas-mediated apoptosis by enhancing caspase-8 activation in cancer cells.
    J. Toxicol. Sci. 44, 435-440 (2019)
    PMID: 31168030
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    2-Sulfonylpyrimidines target the kinesin HSET via cysteine alkylation.
    Eur. J. Org. Chem. 2019, 5486-5496 (2019)
  28. Koyano F, Yamano K, Kosako H, Tanaka K, Matsuda N.
    Parkin recruitment to impaired mitochondria for nonselective ubiquitylation is facilitated by MITOL.
    J. Biol. Chem. 294, 10300-10314 (2019)
    PMID: 31110043
  29. Arii J, Takeshima K, Maruzuru Y, Koyanagi N, Kato A, Kawaguchi Y.
    Roles of the interhexamer Contact Site for Hexagonal Lattice Formation of the Herpes Simplex Virus 1 Nuclear Egress Complex in Viral Primary Envelopment and Replication.
    J. Virol. 93, e00498-19 (2019)
    PMID: 31043535
  30. Murashima A, Shinjo K, Katsushima K, Onuki T, Kondoh Y, Osada H, Kagaya N, Shin-Ya K, Kimura H, Yoshida M, Murakami S, Kondo Y.
    Identification of a chemical modulator of EZH2-mediated silencing by cell-based high-throughput screening assay.
    J. Biochem. 166, 41-50 (2019)
    PMID: 30690451
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    Development of 2-aminoisobutyric acid (Aib)-rich cell-penetrating peptide foldamers for efficient siRNA delivery.
    Chem. Commun. 55, 7792-7795 (2019)
    PMID: 31210205
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    Efficient Ketose Production by Hydroxyapatite Catalyst in a Continuous Flow Module.
    ACS Sustainable Chem. Eng. 7, 3372-3377 (2019)
  33. Mitsui E, Yoshida S, Shinoda Y, Matsumori Y, Tsujii H, Tsuchida M, Wada S, Hasegawa M, Ito A, Mino K, Onuki T, Yoshida M, Sasaki R, Mizukami T.
    Identification of ryuvidine as a KDM5A inhibitor.
    Sci. Rep. 9, 9952 (2019)
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    BAG6 deficiency induces mis-distribution of mitochondrial clusters under depolarization.
    FEBS Open Bio. 9, 1281-1291 (2019)
    PMID: 31125507
  35. Han P, Shichino Y, Schneider-Poetsch T, Mito M, Hashimoto S, Udagawa T, Kohno K, Yoshida M, Mishima Y, Inada T, Iwasaki S.
    Genome-wide survey of ribosome collision.
    bioRxiv
  36. Takase S, Kurokawa R, Kondoh Y, Honda K, Suzuki T, Kawahara T, Ikeda H, Dohmae N, Osada H, Shin-Ya K, Kushiro T, Yoshida M, Matsumoto K.
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    ACS Chem. Biol. 14, 1819-1828 (2019)
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    FAM48A mediates compensatory autophagy induced by proteasome impairment.
    Genes to Cells 24, 559–568 (2019)
    PMID: 31210371
  38. Sasaki K, Himeno A, Nakagawa T, Sasaki Y, Kiyonari H, Iwai K.
    Modulation of autoimmune pathogenesis by T cell-triggered inflammatory cell death.
    Nat. Commun. 10, 3878 (2019)
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  39. Yoshida K, Kondoh Y, Iwahashi F, Nakano T, Honda K, Nagano E, Osada H.
    Abscisic acid derivatives with different alkyl chain lengths activate distinct abscisic acid receptor subfamilies.
    ACS Chem. Biol. 14, 1964-1971 (2019)
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    The E3 ubiquitin ligase MIB2 enhances inflammation by degrading the deubiquitinating enzyme CYLD.
    J. Biol. Chem. 294, 14135–14148 (2019)
    PMID: 31366726
  41. Kamikubo K, Kato H, Kioka H, Yamazaki S, Tsukamoto O, Nishida Y, Asano Y, Imamura H, Kawahara H, Shintani Y, Takashima S.
    A molecular triage process mediated by RING finger protein 126 and BCL2-associated athanogene 6 regulates degradation of G0/G1 switch gene 2.
    J. Biol. Chem. 294, 14562-14573 (2019)
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    Stepwise multipolyubiquitantion of p53 by the E6AP-E6 ubiquitin ligase complex.
    J. Biol. Chem. 294, 14860-14875 (2019)
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    Identification of the Capsid Binding Site in the Herpes Simplex Virus 1 Nuclear Egress Complex and Its Role in Viral Primary Envelopment and Replication.
    J. Virol. 93, e01290-19 (2019)
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    Chemical Synthesis of Cys-Containing Protein via Chemoselective Deprotection with Different Palladium Complexes.
    Org. Lett. 21, 8378-8382 (2019)
    PMID: 31560553
  45. Asatsuma-Okumura T, Ando H, De Simone M, Yamamoto J, Sato T, Shimizu N, Asakawa K, Yamaguchi Y, Ito T, Guerrini L, Handa H.
    p63 is a cereblon substrate involved in thalidomide teratogenicity.
    Nat. Chem. Biol. 15, 1077-1084 (2019)
    PMID: 31591562
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  46. Yokosawa T, Yamada M, Noguchi T, Suzuki S, Hirata Y, Matsuzawa A.
    Pro-caspase-3 protects cells from polymyxin B-induced cytotoxicity by preventing ROS accumulation.
    J. Antibiotics 72, 848-852 (2019)
    PMID: 31371783
  47. Jarzebska N A, Yamaguchi S, Izuta S, Kosaka T, Yamahira S, Nagamune T, Okamoto A.
    Photo-responsive materials with strong cell trapping ability for light-guided manipulation of nonadherent cells.
    Biomater. Sci. 7, 4514-4518 (2019)
    PMID: 31602442
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    Facile access to optically active 2,6-dialkyl-1,5-diazacyclooctanes.
    Chem. Asian J. 14, 4048-4054 (2019)
    PMID: 31381243
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    ChemMedChem 14,1911-1916 (2019)
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    Bio-protocol 9, e3430 (2019)
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    SUMO3 Modification by PIAS1 Modulates Androgen Receptor Cellular Distribution and Stability.
    Cell Commun. Signal. 17, 153 (2019)
    PMID: 31752909
  52. Nomura S, Takahashi H, Suzuki J, Kuwahara M, Yamashita M, Sawasaki T.
    Pyrrothiogatain acts as an inhibitor of GATA family proteins and inhibits Th2 cell differentiation in vitro.
    Sci. Rep. 9,17335 (2019)
    PMID: 31758034
  53. Ohigashi I, Tanaka Y, Kondo K, Fujimori S, Kondo H, Palin AC, Hoffmann V, Kozai M, Matsushita Y, Uda S, Motosugi R, Hamazaki J, Kubota H, Murata S, Tanaka K, Katagiri T, Kosako H, Takahama Y.
    Trans-omics Impact of Thymoproteasome in Cortical Thymic Epithelial Cells.
    Cell Rep. 29, 2901-2916.e6 (2019)
    PMID: 31775054
  54. Abe T, Shizu R, Sasaki T, Shimizu Y, Hosaka T, Kodama S, Matsuzawa A, Yoshinari K.
    Functional interaction between PXR and YAP in xenobiotic-dependent liver hypertrophy and drug metabolism.
    J. Pharmacol. Exp. Ther. 371, 590-601(2019)
    PMID: 31533970
  55. Koyano F, Yamano K, Kosako H, Kimura Y, Kimura M, Fujiki Y, Tanaka K, Matsuda N.
    Parkin-mediated ubiquitylation redistributes MITOL/March5 from mitochondria to peroxisomes.
    EMBO Rep. 20, e47728 (2019)
    PMID: 31602805
    プレスリリース
  56. Ohoka N, Tsuji G, Shoda T, Fujisato T, Kurihara M, Demizu Y, Naito M.
    Development of Small Molecule Chimeras That Recruit AhR E3 Ligase to Target Proteins.
    ACS Chem. Biol. 14, 2822-2832 (2019)
    PMID: 31580635
  57. Kwong MMY, Lee JW, Samian MR, Watanabe N, Osada H, Ong EBB.
    Comparison of microplate- and bottle-based methods to age yeast for chronological life span assays.
    J. Microbiol. Methods. 167 105743 (2019)
    PMID: 31629019
  58. Arata Y, Watanabe A, Motosugi R, Murakami R, Goto T, Hori S, Hirayama S, Hamazaki J, Murata S.
    Defective induction of the proteasome associated with T‐cell receptor signaling underlies T‐cell senescence.
    Genes to Cells 24, 801–813 (2019)
    PMID: 31621149
  59. Sato Y, Tsuchiya H, Yamagata A, Okatsu K, Tanaka, K, Saeki Y, Fukai S.
    Structural insights into ubiquitin recognition and Ufd1 interaction of Npl4.
    Nat. Commun. 10, 5708 (2019)
    PMID: 31836717
    プレスリリース
    http://www.iam.u-tokyo.ac.jp/press_release/191213/
    http://www.igakuken.or.jp/topics/2019/1213.html
    http://www.igakuken.or.jp/english/topics/2019/e-1213.html
  60. Imoto T, Muramatsu M, Miyasaka H, Mizukami S, Kikuchi K.
    Improvement in Photostability of Fluorescein by Lanthanide Ions based on Energy Transfer-Based Triplet State Quenching
    Chem. Lett. 48, 1181–1184 (2019)

 

総説論文・書籍 / Review・Book

  1. *Yoshida M.
    Recent advances in target identification of bioactive natural products.
    Biosci. Biotechnol. Biochem. 83, 1-9 (2019)
    PMID: 30343630
  2. Ohtake F, Tsuchiya H, Tanaka K, *Saeki Y.
    Methods to measure ubiquitin chain length and linkage.
    Methods Enzymol. 618, 105-133 (2019)
    PMID: 30850048
  3. Yoshida Y, Saeki Y, Tsuchiya H, *Tanaka K.
    TR-TUBE system: Method for detecting ubiquitination activity and identifying ubiquitinated substrates.
    Methods Enzymol. 618, 135-147 (2019)
    PMID: 30850049  
  4. Shibata N, Ohoka N, Hattori T, *Naito M.
    Development of a Potent Protein Degrader against Oncogenic BCR-ABL Protein.
    Chem. Pharm. Bull. 67, 165-172 (2019)
    PMID: 30827996
  5. *Naito M, Ohoka N, Shibata N.
    SNIPERs-Hijacking IAP activity to induce protein degradation.
    Drug Discov. Today: Technol. 31, 35-42 (2019)
    PMID: 31200857
  6. Motosugi R, *Murata S.
    Dynamic Regulation of Proteasome Expression.
    Front. Mol. Biosci. 6, 30 (2019)
    PMID: 31119134
  7. *Inada T.
    The mechanism for recycling tRNAs on stalled ribosomes.
    Nat. Struc. Mol. Biol. 26, 340-342 (2019)
    PMID: 31011210
  8. Wei W, Rasul A, Sadiqa A, Sarfraz I, Hussain G, Nageen B, Liu X, Watanabe N, Selamoglu Z, Ali M, *Li X, *Li J.
    Curcumol: From Plant Roots to Cancer Roots.
    Int. J. Biol. Sci. 15, 1600-1609 (2019)
    PMID: 31360103
  9. Asatsuma-Okumura T, Ito T (co-1st author), *Handa H.
    Molecular mechanisms of cereblon-based drugs.
    Pharmacol. Ther. 202, 132-139. (2019)
    PMID: 31202702
  10. *Yashiroda Y, Yoshida M.
    Intraspecies cell-cell communication in yeast.
    FEMS Yeast Res. 19, pii: foz071 (2019)
    PMID: 31688924
  11. *Naito M, Ohoka N, Shibata N, Tsukumo Y.
    Targeted Protein Degradation by Chimeric Small Molecules, PROTACs and SNIPERs.
    Front. Chem. 7, 849 (2019)
    PMID: 31921772
  12. *Inada T.
    The proteasome's balancing act.
    Nat. Plants 5,1203-1204 (2019)
    PMID: 31740771
  13. Ageta H, *Tsuchida K.
    Post-translational modification and protein sorting to small extracellular vesicles including exosomes by ubiquitin and UBLs.
    Cell. Mol. Life Sci. 76,4829-4848 (2019)
    PMID: 31363817

 

日本語総説/ Review in Japanese

  1. 植木将弘、*岩井一宏:「ユビキチン修飾異常による炎症病態〜HOIP変異症・HOIL-1変異症・SHARPIN変異症・OTULIN変異症」炎症と免疫 第27巻第5号363-370 (2019)
  2. *山野晃史:「損傷ミトコンドリアの選択的分解」生化学 第91巻第3号369-379 (2019)
  3. *山野晃史:「マイトファジー:損傷ミトコンドリアの選択的分解」DOJIN NEWS 第171号1-4 (2019)
  4. *内藤幹彦:「SNIPERによるプロテインノックダウン技術と創薬」Medical Science Digest 第45巻第4号 185-186 (2019)
  5. 堀江 透、*内藤幹彦:「質量分析法を用いたタンパク質の絶対定量と標的タンパク質分解誘導薬の開発」PHARM STAGE 第18巻1号1-6 (2019)
  6. *内藤幹彦:「タンパク質の発現を制御する技術と医薬品開発への応用」衛研報告 第137巻1-5 (2019)
  7. *伊藤拓水、半田 宏:「IMiDsの標的因子セレブロン」臨床血液 第60巻第9号1013-1019 (2019)
  8. 上田洋司、*土田邦博:「ユビキチン様タンパク質とエクソソームへのタンパク質輸送制御機構」生化学 第91巻第4号 514-518 (2019)
  9. 福田亮介、*沖米田司:「嚢胞性線維症における上皮細胞の水の輸送障害を理解する」消化器病学サイエンス 第3巻第2号18-22 (2019)
  10. *森戸大介:「もやもや病遺伝子の代謝制御機能」生化学 第91巻第6号815-819 (2019)
  11. *上田 実、高岡洋輔、齋藤大明:「有機化学者が計算化学者に助けてもらってリガンドー受容体間ドッキングによる分子設計に成功するまで」アンサンブル『実験と分子シミュレーションのインタープレイ』第21巻第3号196-203 (2019)
  12. *高岡洋輔:「植物ホルモン共受容体COI1-JAZのサブタイプ選択的リガンドの開発」化学と工業 第72巻第12号 (2019)

 

原著論文 / Publication

  1. Yamashita H, Tomoshige S, Nomura S, Ohgane K, Hashimoto Y, Ishikawa M.
    Application of Protein Knockdown Strategy Targeting β-Sheet Structure to Multiple Disease-associated Polyglutamine Proteins.
    Bioorg. Med. Chem. 28, 115175 (2020)
    PMID: 31767406
  2. Lodochnikova OA, Chulakova DR, Gerasimova DP, Litvinov IA, Pradipta AR, Tanaka K, Kurbangalieva AR.
    Stereochemical features of the crystallization of eight-membered 1,5-diazaheterocycles with chiral aminoindanol fragments at nitrogen atoms.
    J. Struct. Chem. 61, 119-125 (2020)
  3. Mimami S, Yokota N, Kawahara H.
    BAG6 contributes to glucose uptake by supporting the cell surface translocation of the glucose transporter GLUT4.
    Biol. Open 9, bio047324 (2020)
    PMID: 31911483
  4. Mishima Y, Brueckner L, Takahashi S, Kawakami T, Otani J, Shinohara A, Takeshita K, Garvilles RG, Watanabe M, Sakai N, Takeshima H, Nachtegael C, Nishiyama A, Nakanishi M, Arita K, Nakashima K, Hojo H, Suetake I.
    Enhanced processivity of Dnmt1 by monoubiquitinated histone H3.
    Genes Cells 25, 22-32 (2020)
    PMID: 31680384
  5. Yamada M, Suzuki M, Noguchi T, Yokozawa T, Sekiguchi Y, Mutoh N, Toyama T, Hirata Y, Hwang GW, Matsuzawa A.
    The antibiotic cefotaxime works as both an activator of Nrf2 and an inducer of HSP70 in mammalian cells.
    BPB Rep. 3, 16-21 (2020)
  6. Yasuda S, Tsuchiya H, Kaiho A, Guo Q, Ikeuchi K, Endo A, Arai N, Ohtake F, Murata S, Inada T, Baumeister W, Fernandez-Busnadiego R, Tanaka K, Saeki Y.
    Stress- and ubiquitylation-dependent phase separation of the proteasome.
    Nature 578, 296-300 (2020)
    PMID: 32025036
    プレスリリース
    http://www.igakuken.or.jp/topics/2020/0205.html (都医学研)
    https://www.amed.go.jp/news/release_20200206-02.html(AMED)
    Highlighted in Cell Res
    EurekAlert!
    Faculty Opinions
  7. Suvarna K, Honda K, Muroi M, Kondoh Y, Osada H, Watanabe N.
    Measurement of ATPase activity of valosin-containing protein/p97.
    Bio-protocol 10, e3516 (2020)
  8. Suvarna K, Honda K, Muroi M, Kondoh Y, Watanabe N, Osada H.
    Identification of target protein for bio-active small molecule using photo-cross linked beads and MALDI-TOF mass spectrometry.
    Bio-protocol 10, e3517 (2020)
  9. Hirata Y, Inoue A, Suzuki S, Takahashi M, Matsui R, Kono N, Noguchi T, Matsuzawa A.
    trans-Fatty acids facilitate DNA damage-induced apoptosis through the mitochondrial JNK-Sab-ROS positive feedback loop.
    Sci. Rep. 10, 2743 (2020)
    PMID: 32066809
    プレスリリース
    https://www.tohoku.ac.jp/japanese/2020/02/press20200227-02-trance.html
    https://www.tohoku.ac.jp/en/press/how_trans_fats_assist_cell_death.html
  10. Shoda T, Ohoka N, Tsuji G, Fujisato T, Inoue H, Demizu Y, Naito M, Kurihara M.
    Targeted protein degradation by chimeric compounds using hydrophobic E3 ligands and adamantane moiety.
    Pharmaceuticals 13, E34 (2020)
    PMID: 32106507
  11. Brazee PL, Morales-Nebreda L, Magnani ND, Garcia JG, Misharin AV, Ridge KM, Budinger GRS, Iwai K, Dada LA, Sznajder, JI.
    Linear ubiquitin assembly complex regulates lung epithelial-driven responses during influenza infection.
    J. Clin. Invest. 130, 1301-1314 (2020)
    PMID: 31714898
  12. Waku T, Nakamura N, Koji M, Watanabe H, Katoh H, Tatsumi C, Tamura N, Hatanaka A, Hirose S, Katayama H, Tani M, Kubo Y, Hamazaki J, Hamakubo T, Watanabe A, Murata S, Kobayashi A.
    NRF3-POMP-20S Proteasome Assembly Axis Promotes Cancer Development via Ubiquitin-Independent Proteolysis of p53 and Retinoblastoma Protein.
    Mol. Cell. Biol. 40, e597-19 (2020)
    PMID: 32123008
  13. Tateno S, Iida M, Fujii S, Suwa T, Katayama M, Tokuyama H, Yamamoto J, Ito T, Sakamoto S, Handa H, Yamaguchi Y.
    Genome-wide screening reveals a role for subcellular localization of CRBN in the anti-myeloma activity of pomalidomide.
    Sci. Rep. 10,4012 (2020)
    PMID: 32132601
  14. Nishiyama A, Mulholland C, Bultmann S, Kori A, Endo A, Saeki Y, Qin W, Trummer C, Chiba Y, Yokoyama H, Kumamoto S, Kawakami T, Hojo H, Nagae G, Aburatani H, Tanaka K, Arita K, Leonhardt H, Nakanishi M.
    Two distinct modes of DNMT1 recruitment ensure the stable maintenance DNA methylation.
    Nat. Commun. 11, 1222 (2020)
    PMID: 32144273
    プレスリリース
    Faculty Opinions
  15. Shibata N, Ohoka N, Tsuji G, Demizu Y, Akiyama T, Naito M.
    Deubiquitylase USP25 prevents degradation of BCR-ABL protein and ensures proliferation of Ph-positive leukemia cells.
    Oncogene 39,3867-3878 (2020)
    PMID: 32203161
  16. Arafiles JVV, Hirose H, Akishiba M, Tsuji S, Imanishi M, Futaki S.
    Stimulating macropinocytosis for intracellular nucleic acid and protein delivery: a combined strategy with membrane-lytic peptides to facilitate endosomal escape.
    Bioconjug. Chem. 31, 547-553 (2020)
    PMID: 32017537
  17. Matsuo Y, Tesina P, Nakajima S, Mizuno M, Endo A, Buschauer R, Cheng J, Shounai O, Ikeuchi K, Iwasaki S, Saeki Y, Becker T, Beckmann R, Inada T.
    RQT complex dissociates ribosomes collided on endogenous RQC substrate SDD1.
    Nat. Stuct. Mol. Biol. 27, 323-332 (2020)
    PMID: 32203490
    プレスリリース
    https://www.amed.go.jp/news/release_20200324-02.html(AMED)
    https://www.tohoku.ac.jp/japanese/2020/03/press20200324-04-honnyaku.html(東北大学)
    https://www.nikkei.com/article/DGKKZO57329880X20C20A3MY1000/(日経新聞)
  18. Takaoka Y, Miyagawa S, Nakamura A, Egoshi S, Tsukiji S, Ueda M.
    Hoechst-tagged Fluorescein Diacetate for the Fluorescence Imaging-based Assessment of Stomatal Dynamics in Arabidopsis thaliana.
    Sci. Rep. 10, 5333 (2020)
    PMID: 32210301
  19. Yamanaka S, Sato Y, Oikawa D, Goto E, Fukai S, Tokunaga F, Takahashi H, Sawasaki T.
    Subquinocin, a small molecule inhibitor of CYLD and USP-family deubiquitinating enzymes, promotes NF-κB signaling.
    Biochem. Biophys. Res. Commun. 524, 1-7 (2020)
    PMID: 31898971
  20. Naito S, Fukushima T, Endo A, Denda K, Komada M.
    Nik-related kinase is targeted for proteasomal degradation by the chaperone-dependent ubiquitin ligase CHIP.
    FEBS Lett. 594,1778-1786 (2020)
    PMID: 32162334
  21. Tsuchida M, Yokozawa T, Noguchi T, Shimada T, Yamada M, Sekiguchi Y, Hirata Y, Matsuzawa A.
    Pro-apoptotic functions of TRAF2 in p53-mediated apoptosis induced by cisplatin.
    J. Toxicol. Sci. 45, 219-226 (2020)
    PMID: 32238696
  22. Morihiro K, Okamoto A.
    A highly constrained nucleic acid analog based on α-L-threosamine.
    Nucleosides Nucleotides Nucleic Acids 39, 270-279 (2020)
    PMID: 31530088
  23. Luong NC, Abiko Y, Shibata T, Uchida K, Warabi E, Suzuki M, Noguchi T, Matsuzawa A, Kumagai Y.
    Redox cycling of 9,10-phenanthrenequinone activates epidermal growth factor receptor signaling through S-oxidation of protein tyrosine phosphatase 1B.
    J. Toxicol. Sci. 45, 349-363 (2020)
    PMID: 32493877
  24. Wang L, Liu S, Xu J, Watanabe N, Di J, Wei W, Mayo KH, Li J, Li X.
    A traditional Chinese Medicine, YXQN, Reduces Amyloid-induced Cytotoxicity by Inhibiting Aβ42 Aggregation and Fibril Formation.
    Curr. Pharm. Des. 26, 780-789 (2020)
    PMID: 32031066
  25. Chen J, Morihiro K, Fukui D, Guo L, Okamoto A.
    Live-Cell Sensing of Telomerase Activity Using Hybridization-Sensitive Fluorescent Oligonucleotide Probes.
    ChemBioChem 21, 1022-1027 (2020)
    PMID: 31840916
  26. Oikawa D, Sato Y, Ohtake F, Komakura K, Hanada K, Sugawara K, Terawaki S, Mizukami Y, Phuong HT, Iio K, Obika S, Fukushi M, Irie T, Tsuruta D, Sakamoto S, Tanaka K, Saeki Y, Fukai S, Tokunaga F.
    Molecular bases for HOIPINs-mediated inhibition of LUBAC and innate immune responses.
    Commun. Biol. 3, 163 (2020)
    PMID: 32246052
  27. Sugawara E, Kato M, Kudo Y, Lee W, Hisada R, Fujieda Y, Oku K, Bohgaki T, Amengual O, Yasuda S, Onodera T, Hatakeyama S, Atsumi T.
    Autophagy promotes citrullination of VIM (vimentin) and its interaction with major histocompatibility complex class II in synovial fibroblasts.
    Autophagy 16, 946-955 (2020)
    PMID: 31486697
  28. Pradipta AR, Tanei T, Morimoto K, Shimazu K, Noguchi S, Tanaka K.
    Emerging technologies for real-time intraoperative margin assessment in future breast-conserving surgery.
    Adv. Sci. 7, 1901519 (2020)
    PMID: 32382473
  29. Buschauer R, Matsuo Y (co-1st author), Sugiyama T, Chen YH, Alhusaini N, Sweet T, Ikeuchi K, Cheng J, Matsuki Y, Gilmozzi A, Berninghausen O, Becker T, Coller J, Inada T, Beckmann R.
    The Ccr4-Not complex monitors the translating ribosome for codon optimality.
    Science 368, 6448 (2020)
    PMID: 32299921
    プレスリリース
  30. Sugawara E, Kato M, Kudo Y, Lee W, Hisada R, Fujieda Y, Oku K, Bohgaki T, Amengual O, Yasuda S, Onodera T, Hatakeyama S, Atsumi T.
    Autophagy promotes citrullination of VIM (vimentin) and its interaction with major histocompatibility complex class II in synovial fibroblasts,
    Autophagy 16, 946-955(2020)
    PMID: 31486697
  31. Han P, Shichino Y, Schneider-Poetsch T, Mito M, Hashimoto S, Udagawa T, Kohno K, Yoshida M, Mishima Y, Inada T, Iwasaki S.
    Genome-wide survey of ribosome collision.
    Cell Rep. 31,107610 (2020)
    PMID: 32375038
  32. Kuriyama Y, Shimizu A, Kanai S, Oikawa D, Tokunaga F, Tsukagoshi H, Ishikawa O.
    The synchronized gene expression of retrotransposons and type I interferon in dermatomyositis.
    J. Am. Acad. Dermatol. AOP (2020)
    PMID: 32439465
  33. Sako K, Futamura Y, Shimizu T, Matsui A, Hirano H, Kondoh Y, Muroi M, Aono H, Tanaka M, Honda K, Shimizu K, Kawatani M, Nakano T, Osada H, Noguchi K, Seki M.
    Inhibition of mitochondrial complex I by the novel compound FSL0260 enhances high salinity-stress tolerance in Arabidopsis thaliana.
    Sci. Rep. 10, 8691 (2020)
    PMID: 32457324
  34. Fuseya Y, Fujita H, Kim M, Ohtake F, Nishide A, Sasaki K, Saeki Y, Tanaka K, Takahashi R, Iwai K.
    The HOIL-1L ligase modulates immune signalling and cell death via monoubiquitination of LUBAC.
    Nat. Cell Biol. 22, 663-673 (2020)
    PMID: 32393887
    プレスリリース
  35. Tamemoto N, Akishiba M, Sakamoto K, Kawano K, Noguchi H, Futaki S.
    Rational Design Principles of Attenuated Cationic Lytic Peptides for Intracellular Delivery of Biomacromolecules.
    Mol. Pharm. 17, 2175-2185 (2020)
    PMID: 32352304
  36. Takahashi H, Yamanaka S, Kuwada S, Higaki K, Kido K, Sato Y, Fukai S, Tokunaga F, Sawasaki T.
    A Human DUB Protein Array for Clarification of Linkage Specificity of Polyubiquitin Chain and Application to Evaluation of Its Inhibitors.
    Biomedicines 8, 152 (2020)
    PMID: 32512835
  37. Sakamoto K, Akishiba M, Iwata T, Murata K, Mizuno S, Kawano K, Imanishi M, Sugiyama F, Futaki S.
    Optimizing Charge Switching in Membrane Lytic Peptides for Endosomal Release of Biomacromolecules.
    Angew. Chem. Int. Ed. Engl. AOP (2020)
    PMID: 32557993
  38. Nakatsu K, Yanase M, Hayashi G, Okamoto A.
    Fmoc-Compatible and C-terminal-Sequence-Independent Peptide Alkyl Thioester Formation Using Cysteinylprolyl Imide.
    Org. Lett. 22, 4670-4674 (2020)
    PMID: 32484687
  39. Fuseya Y, Fujita H, Kim M, Ohtake F, Nishide A, Sasaki K, Saeki Y, Tanaka K, Takahashi R, Iwai K.
    The HOIL-1L ligase modulates immune signaling and cell death via mono-ubiquitination of LUBAC.
    Nat. Cell Biol. 22, 663-673 (2020)
    PMID: 32393887
    プレスリリース
  40. Jo T, Nishikori M, Kogure Y, Arima H, Sasaki K, Sasaki Y, Nakagawa T, Iwai F, Momose S, Shiraishi A, Kiyonari H, Kagaya N, Onuki T, Shin-Ya K, Yoshida M, Kataoka K, Ogawa S, Iwai K, Takaori-Kondo A.
    LUBAC accelerates B-cell lymphomagenesis by conferring resistance to genotoxic stress on B cells.
    Blood 136, 684–697 (2020)
    PMID: 32325488
    プレスリリース
  41. Kori S, Jimenji T, Ekimoto T, Sato M, Kusano F, Oda T, Unoki M, Ikeguchi M, Arita K.
    Serine 298 phosphorylation in linker 2 of UHRF1 regulates ligand-binding property of its tandem Tudor domain.
    J. Mol. Biol. 432, 4064-4078 (2020)
    PMID: 32428527
  42. Pradipta AR, Chang T C, Tanaka K.
    Enantioselective synthesis of cyclic and linear diamines by iminocycloaddition.
    Chirality 32, 1160-1168 (2020)
    PMID: 32621328
  43. Yamaguchi S,Takagi R, Hosogane T, Ohashi Y, Sakai Y, Sakakihara S, Iino R, Tabata K, Noji H, Okamoto A.
    Single cell array enclosed with a photodegradable hydrogel in microwells for image-based cell classification and selective photorelease of cells.
    ACS Appl. Bio Mater. 3,9, 5887–5895 (2020)
  44. Matsuura Y, Noguchi A, Yokota N, Kawahara H.
    Nuclear accumulation of ZFP36L1 is cell cycle-dependent and determined by a C-terminal serine-rich cluster.
    J. Biochem. 168,477-489 (2020)
    PMID: 32687160
  45. Suzuki G, Imura S, Hosokawa M, Katsumata R, Nonaka T, Hisanaga SI, Saeki Y, Hasegawa M.
    α-Synuclein strains that cause distinct pathologies differentially inhibit proteasome.
    eLife 9, e56825 (2020)
    PMID: 32697196
  46. Hashimoto E, Okuno S, Hirayama S, Arata Y, Goto T, Kosako H, Hamazaki J, Murata S.
    Enhanced O-GlcNAcylation mediates cytoprotection under proteasome impairment by promoting proteasome turnover in cancer cells.
    iScience 23,101299 (2020)
    PMID: 32634741
  47. Yokoo H, Ohoka N, Naito M, Demizu Y.
    Design and synthesis of peptide-based chimeric molecules to induce degradation of the estrogen and androgen receptors.
    Bioorg. Med. Chem. 28,115595 (2020)
    PMID: 32631565
  48. Wang L, Liu S, Xu J, Watanabe N, Mayo KH, Li J, Li X.
    Emodin inhibits aggregation of amyloid-β peptide 1-42 and improves cognitive deficits in Alzheimer's disease transgenic mice.
    J. Neurochem. AOP (2020)
    PMID: 32799401
  49. Ikeda H, Muroi M, Kondoh Y, Ishikawa S, Kakeya H, Osada H, Imoto M.
    Miclxin, a novel MIC60 inhibitor, induces apoptosis via mitochondrial stress in β-catenin mutant tumor cells.
    ACS Chem. Biol. 15, 2195-2204 (2020)
    PMID: 32584541
  50. Kawamura T, Futamura Y, Shang E, Muroi M, Janning P, Ueno M, Wilke J, Takeda S, Kondoh Y, Ziegler S, Watanabe N, Waldmann H, Osada H.
    Discovery of small-molecule modulator of heterotrimeric Gi-protein by integrated phenotypic profiling and chemical proteomics.
    Biosci. Biotech. Biochem. 84, 2484-2490 (2020)
    PMID: 32867616
  51. Yamano K, Kikuchi R, Kojima W, Hayashida R, Koyano F, Kawawaki J, Shoda T, Demizu Y, Naito M, Tanaka K, Matsuda N.
    Critical role of mitochondrial ubiquitination and the OPTN–ATG9A axis in mitophagy.
    J. Cell Biol. 219,e201912144 (2020)
    PMID: 32556086
  52. Kondo T, Iwatani Y, Matsuoka K, Fujino T, Umemoto S, Yokomaku Y, Ishizaki K, Kito S, Sezaki T, Hayashi G, Murakami H.
    Antibody-like proteins that capture and neutralize SARS-CoV-2.
    Sci. Adv. 6, eabd3916 (2020)
    PMID: 32948512
  53. Yamamoto J, Suwa T, Murase Y, Tateno S, Mizutome H, Asatsuma-Okumura T, Shimizu N, Kishi T, Momose S, Kizaki M, Ito T, Yamaguchi Y, Handa H.
    ARID2 is a pomalidomide-dependent CRL4CRBN substrate in multiple myeloma cells.
    Nat. Chem. Biol. 16, 1208-1217 (2020)
    PMID: 32958952
  54. Kowada T, Watanabe T, Amagai Y, Liu R, Yamada M,Takahashi H, Matsui T, Inaba K, Mizukami S.
    Quantitative imaging of labile Zn2+ in the Golgi apparatus using a localizable small-molecule fluorescent probe
    Cell Chem. Biol. AOP(2020)
    プレスリリース
  55. Radwan MO, Ciftci HI, Ali TFS, Koga R, Tateishi H, Nakata A, Ito A, Yoshida M, Fujita M, Otsuka M.
    Structure activity study of S-trityl-cysteamine dimethylaminopyridine derivatives as SIRT2 inhibitors: Improvement of SIRT2 binding and inhibition.
    Bioorg. Med. Chem. Lett. 30,127458 (2020)
    PMID: 32755678
  56. Kobayashi H, Nishimura H, Kudo N, Osada H, Yoshida M.
    A novel GSK3 inhibitor that promotes self-renewal in mouse embryonic stem cells.
    Biosci. Biotechnol. Biochem. 84,2113-2120 (2020)
    PMID: 32640867
  57. Ogata M, Hayashi G, Ichiu A, Okamoto A.
    L-DNA-tagged fluorescence in situ hybridization for highly sensitive imaging of RNAs in single cells.
    Org. Biomol. Chem. 18,8084-8088 (2020)
    PMID: 33001106
  58. Watanabe M, Saeki Y, Takahashi H, Ohtake F, Yoshida Y, Kasuga Y, Kondo T, Yaguchi H, Suzuki M, Ishida H, Tanaka K, Hatakeyama S.
    A substrate-trapping strategy to find E3 ubiquitin ligase substrates identifies Parkin and TRIM28 targets.
    Commun. Biol. 3,592 (2020)
    PMID: 33082525
  59. Fujita K, Kondoh Y, Honda K, Haga Y, Osada H, Matsumura C, Inui H.
    Pesticide treatment reduces hydrophobic pollutant contamination in Cucurbita pepo through competitive binding to major latex-like proteins.
    Environ. Pollut. 266, 115179 (2020)
    PMID: 32717636
  60. Pan Y, Zhao Y, Kuang R, Liu H, Sun D, Mao T, Jiang K, Yang X, Watanabe N, Mayo KH, Lin Q, Li J.
    Injectable hydrogel-loaded nano-hydroxyapatite that improves bone regeneration and alveolar ridge promotion.
    Mater. Sci. Eng., C 116, 111158 (2020)
    PMID: 32806272
  61. Kobayashi H, Hatakeyama H, Nishimura H, Yokota M, Suzuki S, Tomabechi Y, Shirouzu M, Osada H, Mimaki M, *Goto Y, Yoshida M.
    Chemical reversal of abnormalities in cells carrying mitochondrial DNA mutations.
    Nat. Chem. Biol. AOP (2020)
    PMID: 33168978

 

総説論文・書籍 / Review・Book

  1. *Itoh Y.
    Drug Discovery Researches on Modulators of Lysine-Modifying Enzymes Based on Strategic Chemistry Approaches.
    Chem. Pharm. Bull. 68, 34-45 (2020)
    PMID: 31902900
  2. Takaoka Y, Hayashi K, Suzuki K, Azizah IN, * Ueda M.
    A Fluorescence Anisotropy-Based Comprehensive Method for the In Vitro Screening of COI1-JAZs Agonists and Antagonists.
    Methods Mol. Biol. 2085, 145-160 (2020)
    PMID: 31734923
  3. Ito T, *Handa H.
    Molecular mechanisms of thalidomide and its derivatives.
    Proc. Jpn. Acad. Ser. B Phys. Biol. Sci. 96,189-203 (2020)
    PMID: 32522938
  4. *Inada T.
    Quality controls induced by aberrant translation.
    Nucleic Acids Res. 48, 1084-1096 (2020)
    PMID: 31950154
  5. *Matsuda N, Yamano K.
    Two sides of a coin: physiological significance and molecular mechanisms for damage-induced mitochondrial localization of PINK1 and Parkin.
    Neurosci. Res. AOP (2020)
    PMID: 32201358
  6. Fukuda R, *Okiyoneda T.
    Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Ubiquitylation as a Novel Pharmaceutical Target for Cystic Fibrosis.
    Pharmaceuticals(Basel) 13,75 (2020)
    PMID: 32331485
  7. *Ishikawa M, Tomoshige S, Demizu Y, Naito M.
    Selective Degradation of Target Proteins by Chimeric Small-Molecular Drugs, PROTACs and SNIPERs.
    Pharmaceuticals 13,74 (2020)
    PMID: 32326273
  8. Asatsuma-Okumura T, *Ito T, Handa H.
    Molecular Mechanisms of the Teratogenic Effects of Thalidomide.
    Pharmaceuticals 96,189-203 (2020)
    PMID: 32414180
  9. Oikawa D, Sato Y, Ito H, *Tokunaga F.
    Linear ubiquitin code: Its writer, erasers, decoders, inhibitors, and implications in disorders.
    Int. J. Mol. Sci. 21,E3381, 2020.
    PMID: 32403254
  10. Tomoshige S, *Ishikawa M.
    PROTACs and Other Chemical Protein Degradation Technologies for the Treatment of Neurodegenerative Disorders.
    Angew. Chem. Int. Ed. AOP (2020)
  11. Nakatsu K, *Hayashi G, *Okamoto A.
    Toolbox for chemically synthesized histone proteins.
    Curr. Opin. Chem. Biol. 58, 10-19 (2020)
    PMID: 32473259
  12. *Ohtake F.
    Mass Spectrometry Technologies for Deciphering the Ubiquitin Code.
    Trends Biochem. Sci. 45, 820-821 (2020)
    PMID: 32423745
  13. Tsuchiya H, Endo A, *Saeki Y.
    Multi-Step Ubiquitin Decoding Mechanism for Proteasomal Degradation.
    Pharmaceuticals(Basel). 13, E128 (2020)
    PMID: 32585960

 

日本語総説/ Review in Japanese

  1. 村田茂穂、池浦隆真:「タンパク質分解装置プロテアソームと創薬」ファルマシア『ケモテクノロジーが拓くユビキチン創薬研究の新展開』第56巻第1号11-15 (2020)
  2. *山野晃史:「不良ミトコンドリア分解を司るParkinとPINK1」ファルマシア『ケモテクノロジーが拓くユビキチン創薬研究の新展開』第56巻第1号16-20 (2020)
  3. *佐伯 泰:「最先端プロテオミクス解析を用いたユビキチン研究」ファルマシア『ケモテクノロジーが拓くユビキチン創薬研究の新展開』第56 巻第1号21-25 (2020)
  4. *沖米田司:「嚢胞性線維症のユビキチン創薬」ファルマシア『ケモテクノロジーが拓くユビキチン創薬研究の新展開』第56巻第1 号31-35 (2020)
  5. *西山敦哉:「DNA維持メチル化機構を制御するユビキチンシグナル」ファルマシア『ケモテクノロジーが拓くユビキチン創薬研究の新展開』第56 巻第1号36-40 (2020)
  6. 大岡伸通、*内藤幹彦:「新しい低分子薬の創薬モダリティPROTAC」ファルマシア『ケモテクノロジーが拓くユビキチン創薬研究の新展開』第56 巻第1号41-45 (2020)
  7. *林 剛介:「タンパク質化学合成を活用した翻訳後修飾研究」ファルマシア『ケモテクノロジーが拓くユビキチン創薬研究の新展開』第56巻第1号46-50 (2020)
  8. *高橋宏隆、山中聡士:「コムギ無細胞合成系による脱ユビキチン化酵素アレイの作製とDUB阻害剤開発への応用」ファルマシア『ケモテクノロジーが拓くユビキチン創薬研究の新展開』第56巻第1号 51-55, (2020)
  9. 土屋 光、*佐伯 泰:「細胞内のユビキチン鎖長解析」生化学『非定型型ユビキチン鎖の生理機能』第92巻第1号14-19 (2020)
  10. *佐々木克博、*岩井一宏:「直鎖状ユビキチン鎖を生成するLUBACリガーゼの構造、機能、T細胞機能制御」生化学『非定型型ユビキチン鎖の生理機能』第92巻第1号20-27 (2020)
  11. *及川大輔、伊東秀文、徳永文稔:「直鎖状ユビキチン鎖の神経変性疾患への関与とLUBAC阻害剤の開発」生化学『非定型型ユビキチン鎖の生理機能』第92巻第1号 28-34 (2020)
  12. 濱崎 純、村田茂穂:「26Sプロテアソームによるユビキチン化タンパク質認識/分解機構」生化学『非定型型ユビキチン鎖の生理機能』第92巻第1号48-56 (2020)
  13. *大竹史明:「分岐型ユビキチン鎖とアセチル化ユビキチン」生化学『非定型型ユビキチン鎖の生理機能』第92巻第1号57-63 (2020)
  14. *高橋宏隆、山中聡士、徳永文稔、澤崎達也:「ヒト脱ユビキチン化酵素タンパク質アレイの開発とその応用例」生化学『非定型型ユビキチン鎖の生理機能』第92巻第1号64-74 (2020)
  15. 安田さや香、田中啓二、*佐伯 泰:「タンパク質のマルチバレント相互作用が駆動するLLPS」実験医学『構造生命科学からトランススケール・イメージングによる細胞動態学へ』第38巻第5号756-761 (2020)
  16. 伊藤拓水、山口雄輝、*半田 宏 「サリドマイド胎芽症の発症メカニズム」 サリドマイド胎芽症診療ガイド (2020)
  17. *水上 進:「生体分子反応を制御する」CSJ Current Review 36日本化学会編(化学同人,2020年),Chapter II-2章 「光による生体分子反応の制御」,p.51–56.
  18. 安田さや香、土屋 光、遠藤彬則、*佐伯 泰:カレントトピックス「液- 液相分離による核内タンパク質分解機構の発見」実験医学 第38巻第8号1358-1362 (2020)
  19. 福田亮介, *沖米田司:「嚢胞性線維症原因遺伝子産物CFTRの品質管理機構と機能制御」生化学 第92巻第2号179-188(2020)
  20. *川原裕之、南 雪也、宮内真帆、高橋俊樹:「ミニレヴュー:プレエンプティブ品質管理を介した膜タンパク質の選択的分解機構」生化学 第92巻第2号 1-6 (2020)
  21. *林 剛介、*岡本晃充:「タンパク質化学合成を加速するペプチドライゲーションの新技術」有機合成化学協会誌 78 巻第2号130-139 (2020)
  22. 高岡洋輔、*上田 実:「植物ホルモン・ジャスモン酸の多様な活性を制御するケミカルツールの合理的設計:植物の生長と防御を操作する化合物の創製」化学と生物 第58巻第4号200-201 (2020)
  23. *石川 稔、橋本祐一:「生細胞内の疾患関連タンパク質を減少させる低分子創薬手法の開発」有機合成化学協会誌 特集号「ニューモダリティ:有機合成化学の新しい可能性」第78巻5号229-239 (2020)
  24. 柴田識人、*内藤幹彦:「選択的なタンパク質分解誘導剤SNIPERsとPROTACs」臨床免疫・アレルギー科 第73 巻5号540-546 (2020)
  25. *高岡洋輔:「ジャスモン酸受容体のサブタイプ選択性を制御する化合物の創製研究」植物の生長調節, vol. 55, No. 1 (2020)
  26. *石川 稔:「疾患疾患原因タンパク質の寿命を短縮する分子の創製と医薬応用への課題」Drug Delivery System 第35巻3号 229 - 239 (2020)
  27. *西山敦哉、中西 真:「DNAメチル化複製機構」ニューサイエンス社 月刊「細胞」8月号 52(9), (2020)
  28. *福嶋俊明、川口紘平:「コラーゲンの細胞内輸送の分子機構 -脱ユビキチン化酵素USP8による輸送制御」FRAGRANCE JOURNAL 8月号 (2020)
  29. *内藤幹彦:「プロテインノックダウン技術の沿革と今後の展開」実験医学 第38巻14号2300−2304 (2020)
  30. 大岡伸通、内藤幹彦:「キメラ化合物PROTAC/SNIPERの作用機序と新たな開発の動向」実験医学 第38巻14号 2321-2325 (2020)
  31. 友重秀介、石川 稔:「神経変性疾患治療に向けたタンパク質分解アプローチ」実験医学 第38巻14号 2326 - 2330 (2020)
  32. 柴田識人、内藤幹彦:「脱ユビキチン化酵素阻害によるプロテインノックダウン」実験医学 第38巻14号 2337-2341 (2020)
  33. 大岡伸通、内藤幹彦:「標的タンパク質を分解する新しい低分子医薬モダリティ」実験医学 第38巻15号 2644-2650 (2020)